Il est également connu sous le nom de Genome polyprotein. Zika Virus NS1 a une masse de 378.74kDa et une longueur d'acide aminé de 3419.
Nous proposons 4 des anticorps contre Zika Virus NS1, élevé dans Lapin, qui sont appropriés pour le WB, ELISA et IP.
Informations sur les Gènes et les Protéines
Résumé UniProt
Plays a role in virus budding by binding to the cell membrane and gathering the viral RNA into a nucleocapsid that forms the core of the mature virus particle. During virus entry, may induce genome penetration into the host cytoplasm after hemifusion induced by the surface proteins. Can migrate to the cell nucleus where it modulates host functions.
Similitudes de séquence
In the N-terminal section; belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0-1 NS5-type methyltransferase family.
Modification post-traductionnelle
Specific enzymatic cleavages in vivo yield mature proteins. Cleavages in the lumen of endoplasmic reticulum are performed by host signal peptidase, whereas cleavages in the cytoplasmic side are performed by serine protease NS3. Signal cleavage at the 2K-4B site requires a prior NS3 protease-mediated cleavage at the 4A-2K site.
Localisation cellulaire
Virion. Host nucleus. Host cytoplasm. Host cytoplasm > Host perinuclear region.
