ZDHHC9 est un gène codé par le symbole ZDHHC9. Il est également connu sous le nom de: Palmitoyltransferase Zinc finger DHHC domain-containing protein 9; DHHC-9; Zinc finger protein 379; Zinc finger protein 380; CXorf11; ZDHHC10; ZNF379; ZNF380. ZDHHC9 a une masse de 40.92kDa, une longueur d'acide aminé de 364, et est impliqué dans Mental retardation, X-linked, syndromic, ZDHHC9-related.
Nous proposons 8 des anticorps contre ZDHHC9, élevé dans Lapin, qui sont appropriés pour le WB, IHC, ELISA et IP avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS.
Résumé Entrez
This gene encodes an integral membrane protein that is a member of the zinc finger DHHC domain-containing protein family. The encoded protein forms a complex with golgin subfamily A member 7 and functions as a palmitoyltransferase. This protein specifically palmitoylates HRAS and NRAS. Mutations in this gene are associated with X-linked cognitive disability. Alternate splicing results in multiple transcript variants that encode the same protein.
Spécificité tissulaire
Highly expressed in kidney, skeletal muscle, brain, lung and liver. Absent in thymus, spleen and leukocytes.
Implication dans la maladie
Mental retardation, X-linked, syndromic, ZDHHC9-related: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Some MRXSZ patients have marfanoid habitus as an additional feature.
Similitudes de séquence
Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.
Localisation cellulaire
Endoplasmic reticulum membrane. Golgi apparatus membrane.
