Vitamin D Binding protein est un gène codé par le symbole GC. Il est également connu sous le nom de: Vitamin D-binding protein; DBP; Gc protein-derived macrophage activating factor; Gc-MAF; Gc-globulin; Group-specific component; Gc; Vitamin D-binding protein-macrophage activating factor; DBP-maf; GC. Vitamin D Binding protein a une masse de 52.92kDa et une longueur d'acide aminé de 474.
Nous proposons 10 des anticorps contre Vitamin D Binding protein, élevé dans Lapin, Souris et Chèvre, qui sont appropriés pour le WB, IHC et ELISA avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation.
Résumé Entrez
The protein encoded by this gene belongs to the albumin gene family. It is a multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid and on the surface of many cell types. It binds to vitamin D and its plasma metabolites and transports them to target tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Spécificité tissulaire
Expressed in the liver. Found in plasma, ascites, cerebrospinal fluid and urine.
Similitudes de séquence
Belongs to the ALB/AFP/VDB family.
Modification post-traductionnelle
Allele GC*1S is O-glycosylated at Thr-436 (PubMed:20079467). The trisaccharide sugar moiety can be modified by the successive removal of neuraminic acid and galactose leaving an O-mceeN-acetyl-galactosamine. This conversion is thought to produce a macrophage-activating factor (Gc-MAF). Only a minor proportion of plasma GC is O-glycosylated (PubMed:17360250). The potential N-glycosylation site predicted at Asn-288 is thought to be nonglycosylated.
Localisation cellulaire
Secreted.
