VGF est un gène codé par le symbole VGF. Il est également connu sous le nom de Neurosecretory protein VGF. VGF a une masse de 67.26kDa et une longueur d'acide aminé de 615.
Nous proposons 7 des anticorps contre VGF, élevé dans Lapin, qui sont appropriés pour le WB, IHC et ELISA avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Secreted polyprotein that is packaged and proteolytically processed by prohormone convertases PCSK1 and PCSK2 in a cell-type-specific manner (By similarity). VGF and peptides derived from its processing play many roles in neurogenesis and neuroplasticity associated with learning, memory, depression and chronic pain (By similarity).
Résumé Entrez
This gene is specifically expressed in a subpopulation of neuroendocrine cells, and is upregulated by nerve growth factor. The structural organization of this gene is similar to that of the rat gene, and both the translated and the untranslated regions show a high degree of sequence similarity to the rat gene. The encoded secretory protein also shares similarities with the secretogranin/chromogranin family, however, its exact function is not known.
Spécificité tissulaire
Central and peripheral nervous systems, synthesized exclusively in neuronal and neuroendocrine cells.
Modification post-traductionnelle
Multiple peptides are derived from VGF, with activities in synaptic plasticity, antidepression, penile erection, autonomic activation, and increases in energy expenditure.
Localisation cellulaire
Secreted. Cytoplasmic vesicle > Secretory vesicle.
Stored in secretory vesicles and then secreted, NERP peptides colocalize with vasopressin in the storage granules of hypothalamus.
