VEGFB est un gène codé par le symbole VEGFB. Il est également connu sous le nom de: Vascular endothelial growth factor B; VEGF-B; VEGF-related factor; VRF. VEGFB a une masse de 21.6kDa et une longueur d'acide aminé de 207.
Nous proposons 7 des anticorps contre VEGFB, élevé dans Lapin et Human, qui sont appropriés pour le WB, IHC, ELISA et ICC/IF avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Growth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis.
Résumé Entrez
This gene encodes a member of the PDGF (platelet-derived growth factor)/VEGF (vascular endothelial growth factor) family. The VEGF family members regulate the formation of blood vessels and are involved in endothelial cell physiology. This member is a ligand for VEGFR-1 (vascular endothelial growth factor receptor 1) and NRP-1 (neuropilin-1). Studies in mice showed that this gene was co-expressed with nuclear-encoded mitochondrial genes and the encoded protein specifically controlled endothelial uptake of fatty acids. Alternatively spliced transcript variants encoding distinct isoforms have been identified.
Spécificité tissulaire
Expressed in all tissues except liver. Highest levels found in heart, skeletal muscle and pancreas.
Similitudes de séquence
Belongs to the PDGF/VEGF growth factor family.
Modification post-traductionnelle
VEGF-B186 is O-glycosylated.
Localisation cellulaire
Secreted.
Secreted but remains associated to cells or to the extracellular matrix unless released by heparin.
