VAMP2 est un gène codé par le symbole VAMP2. Il est également connu sous le nom de: Vesicle-associated membrane protein 2; VAMP-2; Synaptobrevin-2; SYB2. VAMP2 a une masse de 12.66kDa et une longueur d'acide aminé de 116.
Nous proposons 6 des anticorps contre VAMP2, élevé dans Lapin et Souris, qui sont appropriés pour le WB, IHC, ELISA et ICC/IF avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Involved in the targeting and/or fusion of transport vesicles to their target membrane. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1.
Résumé Entrez
The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is thought to participate in neurotransmitter release at a step between docking and fusion. The protein forms a stable complex with syntaxin, synaptosomal-associated protein, 25 kD, and synaptotagmin. It also forms a distinct complex with synaptophysin. It is a likely candidate gene for familial infantile myasthenia (FIMG) because of its map location and because it encodes a synaptic vesicle protein of the type that has been implicated in the pathogenesis of FIMG.
Spécificité tissulaire
Nervous system and skeletal muscle.
Similitudes de séquence
Belongs to the synaptobrevin family.
Modification post-traductionnelle
Phosphorylated by PRKCZ in vitro and this phosphorylation is increased in the presence of WDFY2.
Localisation cellulaire
Cytoplasmic vesicle > Secretory vesicle > Synaptic vesicle membrane. Cell junction > Synapse > Synaptosome. Cell membrane.
Neuronal synaptic vesicles. Colocalizes with PRKCZ and WDFY2 in intracellular vesicles (PubMed:17313651).
