UDP glucose dehydrogenase est un gène codé par le symbole UGDH. Il est également connu sous le nom de: UDP-glucose 6-dehydrogenase; UDP-Glc dehydrogenase; UGDH. UDP glucose dehydrogenase a une masse de 55.02kDa et une longueur d'acide aminé de 494.
Nous proposons 10 des anticorps contre UDP glucose dehydrogenase, élevé dans Lapin et Souris, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF, Cytométrie en Flux, IP et Dot avec des échantillons dérivés de Humain, Souris, Rat et Bovin.
Informations sur les Gènes et les Protéines
Résumé UniProt
Catalyzes the formation of UDP-alpha-D-glucuronate, a constituent of complex glycosaminoglycans (PubMed:21961565, PubMed:21502315, PubMed:23106432, PubMed:22123821, PubMed:25478983, PubMed:27966912, PubMed:30420606, PubMed:30457329). Required for the biosynthesis of chondroitin sulfate and heparan sulfate. Required for embryonic development via its role in the biosynthesis of glycosaminoglycans (By similarity).
Résumé Entrez
The protein encoded by this gene converts UDP-glucose to UDP-glucuronate and thereby participates in the biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. These glycosylated compounds are common components of the extracellular matrix and likely play roles in signal transduction, cell migration, and cancer growth and metastasis. The expression of this gene is up-regulated by transforming growth factor beta and down-regulated by hypoxia. Alternative splicing results in multiple transcript variants.
Spécificité tissulaire
Detected in heart, placenta, liver, pancreas, spleen, thymus, prostate, ovary, small intestine and colon (PubMed:9737970). Widely expressed (PubMed:9737970).
Similitudes de séquence
Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.
