TYK2 est un gène codé par le symbole TYK2. Il est également connu sous le nom de Non-receptor tyrosine-protein kinase TYK2. TYK2 a une masse de 133.65kDa, une longueur d'acide aminé de 1187, et est impliqué dans Immunodeficiency 35.
Nous proposons 11 des anticorps contre TYK2, élevé dans Lapin, qui sont appropriés pour le WB, IHC, ELISA et ICC/IF avec des échantillons dérivés de Humain, Souris, Rat et Singe.
Informations sur les Gènes et les Protéines
Résumé UniProt
Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.
Résumé Entrez
This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E.
Spécificité tissulaire
Observed in all cell lines analyzed. Expressed in a variety of lymphoid and non-lymphoid cell lines.
Implication dans la maladie
Immunodeficiency 35: A primary immunodeficiency characterized by recurrent skin abscesses, pneumonia, and highly elevated serum IgE.
Similitudes de séquence
Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.
