TWF2 est un gène codé par le symbole TWF2. Il est également connu sous le nom de: Twinfilin-2; A6-related protein; hA6RP; Protein tyrosine kinase 9-like; Twinfilin-1-like protein; PTK9L. TWF2 a une masse de 39.55kDa et une longueur d'acide aminé de 349.
Nous proposons 7 des anticorps contre TWF2, élevé dans Lapin, qui sont appropriés pour le WB, IHC et IP avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles. May play a role in regulating the mature length of the middle and short rows of stereocilia (By similarity).
Résumé Entrez
The protein encoded by this gene was identified by its interaction with the catalytic domain of protein kinase C-zeta. The encoded protein contains an actin-binding site and an ATP-binding site. It is most closely related to twinfilin (PTK9), a conserved actin monomer-binding protein.
Spécificité tissulaire
Ubiquitously expressed (at protein level).
Similitudes de séquence
Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.
Modification post-traductionnelle
In vitro, phosphorylated by PRKCZ, CK2 and SRC.
Localisation cellulaire
Cytoplasm > Cytoskeleton. Cytoplasm > Perinuclear region. Cell projection > Stereocilium.
Perinuclear and G-actin-rich cortical actin structure sublocalization.
