TrkC est un gène codé par le symbole NTRK3. Il est également connu sous le nom de: NT-3 growth factor receptor; GP145-Trk-C; Neurotrophic tyrosine kinase receptor type 3 tyrosine kinase; NTRK3. TrkC a une masse de 94.43kDa et une longueur d'acide aminé de 839.
Nous proposons 9 des anticorps contre TrkC, élevé dans Lapin et Souris, qui sont appropriés pour le WB, IHC, ELISA et ICC/IF avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation.
Résumé Entrez
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene.
Spécificité tissulaire
Widely expressed but mainly in nervous tissue. Isoform 2 is expressed at higher levels in adult brain than in fetal brain.
Similitudes de séquence
Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
Modification post-traductionnelle
Ligand-mediated auto-phosphorylation.
Localisation cellulaire
Membrane.
