Anticorps TrkA + TrkB + TrkC

17 produits

TrkA + TrkB + TrkC est un gène codé par le symbole NTRK1. Il est également connu sous le nom de: High affinity nerve growth factor receptor; Neurotrophic tyrosine kinase receptor type 1; TRK1-transforming tyrosine kinase protein; Tropomyosin-related kinase A; Tyrosine kinase receptor; Tyrosine kinase receptor A; Trk-A; gp140trk; p140-TrkA; NTRK1; MTC; TRK; TRKA. TrkA + TrkB + TrkC a une masse de 87.5kDa, une longueur d'acide aminé de 796, et est impliqué dans Congenital insensitivity to pain with anhidrosis.

Nous proposons 17 des anticorps contre TrkA + TrkB + TrkC, élevé dans Lapin, qui sont appropriés pour le WB, IHC, ELISA et ICC/IF avec des échantillons dérivés de Humain, Souris et Rat.

Informations sur les Gènes et les Protéines

Résumé UniProt
Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand (PubMed:1850821, PubMed:1849459, PubMed:1281417, PubMed:8325889, PubMed:15488758, PubMed:22649032, PubMed:17196528, PubMed:27445338). Can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival (By similarity). Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation (PubMed:1281417). Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival. Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival. Through SHC1 and SH2B1 controls a Ras-PI3 kinase-AKT1 signaling cascade that is also regulating survival. In absence of ligand and activation, may promote cell death, making the survival of neurons dependent on trophic factors.
Résumé Entrez
This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, cognitive disability and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date.
Spécificité tissulaire
Isoform TrkA-I is found in most non-neuronal tissues. Isoform TrkA-II is primarily expressed in neuronal cells. TrkA-III is specifically expressed by pluripotent neural stem and neural crest progenitors.
Implication dans la maladie
Congenital insensitivity to pain with anhidrosis: Characterized by a congenital insensitivity to pain, anhidrosis (absence of sweating), absence of reaction to noxious stimuli, self-mutilating behavior, and mental retardation. This rare autosomal recessive disorder is also known as congenital sensory neuropathy with anhidrosis or hereditary sensory and autonomic neuropathy type IV or familial dysautonomia type II.
Similitudes de séquence
Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
Modification post-traductionnelle
Ligand-mediated autophosphorylation (PubMed:2927393, PubMed:1281417, PubMed:15488758, PubMed:7510697, PubMed:8155326, PubMed:8325889, PubMed:27676246, PubMed:28177573). Interaction with SQSTM1 is phosphotyrosine-dependent. Autophosphorylation at Tyr-496 mediates interaction and phosphorylation of SHC1 (PubMed:15488758, PubMed:7510697, PubMed:8155326, PubMed:8325889).
Localisation cellulaire
Cell membrane. Early endosome membrane. Late endosome membrane. Recycling endosome membrane.

Rapidly internalized after NGF binding (PubMed:1281417). Internalized to endosomes upon binding of NGF or NTF3 and further transported to the cell body via a retrograde axonal transport. Localized at cell membrane and early endosomes before nerve growth factor (NGF) stimulation. Recruited to late endosomes after NGF stimulation. Colocalized with RAPGEF2 at late endosomes.
Western Blot - Anti-TrkA +TRkB + TrkC Antibody [ARC2649] (A309687) - Antibodies.com
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Immunohistochemistry - Anti-Trk A (phospho Tyr701) Antibody (A8070) - Antibodies.com
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Voir le roduitTaille d'Essai de 10µg
ELISA - Anti-Trk A (phospho Tyr496) Antibody (P12-1060) - Antibodies.com
(2)
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ELISA - Anti-Trk A (phospho Tyr701) Antibody (P12-1194) - Antibodies.com
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Western Blot - Anti-TrkA + TrkB + TrkC Antibody (A306771) - Antibodies.com
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Immunohistochemistry - Anti-Trk A Antibody (B8070) - Antibodies.com
(2)
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ELISA - Anti-Trk A (phospho Tyr680+Tyr681) Antibody (P12-1193) - Antibodies.com
(2)
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ELISA - Anti-Trk A (phospho Tyr680+Tyr681) Antibody (P12-1061) - Antibodies.com
(2)
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Western Blot - Anti-Trk A (phospho Tyr680+Tyr681) Antibody (A8071) - Antibodies.com
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Western Blot - Anti-Trk A Antibody (B0589) - Antibodies.com
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Immunohistochemistry - Anti-Trk A (phospho Tyr757) Antibody (A8194) - Antibodies.com
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Immunofluorescence - Anti-Trk A Antibody (B0034) - Antibodies.com
(2)
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Western Blot - Anti-Trk A Antibody (R12-2389) - Antibodies.com
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Western Blot - Anti-TrkA + TrkB + TrkC Antibody [ARC59539] (A309759) - Antibodies.com
(2)
Western Blot - Anti-Trk A Antibody (R12-2388) - Antibodies.com
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Immunohistochemistry - Anti-Trk A (phospho Tyr791) Antibody (A0034) - Antibodies.com
(2)
Voir le roduitTaille d'Essai de 10µg

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