TRIM29 est un gène codé par le symbole TRIM29. Il est également connu sous le nom de: Tripartite motif-containing protein 29; Ataxia telangiectasia group D-associated protein; ATDC. TRIM29 a une masse de 65.84kDa et une longueur d'acide aminé de 588.
Nous proposons 8 des anticorps contre TRIM29, élevé dans Lapin, Souris et Chèvre, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF et Cytométrie en Flux avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of proinflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of STING1 in a similar way, leading to its degradation.
Résumé Entrez
The protein encoded by this gene belongs to the TRIM protein family. It has multiple zinc finger motifs and a leucine zipper motif. It has been proposed to form homo- or heterodimers which are involved in nucleic acid binding. Thus, it may act as a transcriptional regulatory factor involved in carcinogenesis and/or differentiation. It may also function in the suppression of radiosensitivity since it is associated with ataxia telangiectasia phenotype.
Spécificité tissulaire
Expressed in placenta, prostate and thymus.
Modification post-traductionnelle
Constitutively phosphorylated by PKC on serine/threonine in A431 cells.
Localisation cellulaire
Cytoplasm. Lysosome.
Colocalizes with intermediate filaments.
