TRF1 est un gène codé par le symbole TERF1. Il est également connu sous le nom de: Telomeric repeat-binding factor 1; NIMA-interacting protein 2; TTAGGG repeat-binding factor 1; Telomeric protein Pin2/TERF1; PIN2; TRBF1; TRF. TRF1 a une masse de 50.25kDa et une longueur d'acide aminé de 439.
Nous proposons 12 des anticorps contre TRF1, élevé dans Lapin, Souris et Chèvre, qui sont appropriés pour le WB, IHC, ELISA et ICC/IF avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways.
Résumé Entrez
This gene encodes a telomere specific protein which is a component of the telomere nucleoprotein complex. This protein is present at telomeres throughout the cell cycle and functions as an inhibitor of telomerase, acting in cis to limit the elongation of individual chromosome ends. The protein structure contains a C-terminal Myb motif, a dimerization domain near its N-terminus and an acidic N-terminus. Two transcripts of this gene are alternatively spliced products.
Spécificité tissulaire
Highly expressed and ubiquitous. Isoform Pin2 predominates.
Modification post-traductionnelle
Phosphorylated preferentially on Ser-219 in an ATM-dependent manner in response to ionizing DNA damage.
Localisation cellulaire
Nucleus. Cytoplasm > Cytoskeleton > Spindle. Chromosome > Telomere.
Colocalizes with telomeric DNA in interphase and prophase cells. Telomeric localization decreases in metaphase, anaphase and telophase. Associates with the mitotic spindle.
