Transaldolase 1 est un gène codé par le symbole TALDO1. Il est également connu sous le nom de: Transaldolase; TALDO1; TAL; TALDO; TALDOR. Transaldolase 1 a une masse de 37.54kDa, une longueur d'acide aminé de 337, et est impliqué dans Transaldolase deficiency.
Nous proposons 9 des anticorps contre Transaldolase 1, élevé dans Lapin, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF, IP et Dot avec des échantillons dérivés de Humain, Souris, Rat et S. cerevisiae.
Informations sur les Gènes et les Protéines
Résumé UniProt
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
Résumé Entrez
Transaldolase 1 is a key enzyme of the nonoxidative pentose phosphate pathway providing ribose-5-phosphate for nucleic acid synthesis and NADPH for lipid biosynthesis. This pathway can also maintain glutathione at a reduced state and thus protect sulfhydryl groups and cellular integrity from oxygen radicals. The functional gene of transaldolase 1 is located on chromosome 11 and a pseudogene is identified on chromosome 1 but there are conflicting map locations. The second and third exon of this gene were developed by insertion of a retrotransposable element. This gene is thought to be involved in multiple sclerosis.
Implication dans la maladie
Transaldolase deficiency: An inborn error of the pentose phosphate pathway resulting in early-onset multisystem disease. Clinical features include growth retardation, dysmorphic features, cutis laxa, congenital heart disease, hepatosplenomegaly, telangiectases of the skin, pancytopenia, and bleeding tendency.
Similitudes de séquence
Belongs to the transaldolase family. Type 1 subfamily.
Localisation cellulaire
Cytoplasm.
