Anticorps Topoisomerase II alpha+Topoisomerase II beta

13 produits

Topoisomerase II alpha+Topoisomerase II beta est un gène codé par le symbole TOP2A. Il est également connu sous le nom de: DNA topoisomerase 2-alpha; DNA topoisomerase II, alpha isozyme; TOP2A; TOP2. Topoisomerase II alpha+Topoisomerase II beta a une masse de 174.39kDa et une longueur d'acide aminé de 1531.

Nous proposons 13 des anticorps contre Topoisomerase II alpha+Topoisomerase II beta, élevé dans Lapin et Souris, qui sont appropriés pour le WB, IHC, ELISA et ICC/IF avec des échantillons dérivés de Humain, Souris et Rat.

Informations sur les Gènes et les Protéines

Résumé UniProt
Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes. May play a role in regulating the period length of ARNTL/BMAL1 transcriptional oscillation (By similarity).
Résumé Entrez
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia.
Similitudes de séquence
Belongs to the type II topoisomerase family.
Modification post-traductionnelle
Phosphorylation has no effect on catalytic activity. However, phosphorylation at Ser-1106 by CSNK1D/CK1 promotes DNA cleavable complex formation.
Localisation cellulaire
Cytoplasm. Nucleus > Nucleoplasm.

Generally located in the nucleoplasm.
Western Blot - Anti-TOP2A Antibody (C10345) - Antibodies.com
(5)
Voir le roduitTaille d'Essai de 10µg
Western Blot - Anti-TOP2A Antibody (B8439) - Antibodies.com
(4)
Voir le roduitTaille d'Essai de 10µg
Western Blot - Anti-TOP2A (phospho Ser1525) Antibody (A8439) - Antibodies.com
(3)
Voir le roduitTaille d'Essai de 10µg
ELISA - Anti-TOP2A (phospho Ser1525) Antibody (P12-1191) - Antibodies.com
(2)
Voir le roduitTaille d'Essai de 10µg
Immunohistochemistry - Anti-Topoisomerase II alpha Antibody (V0132) - Antibodies.com
(4)
Voir le roduitTaille d'Essai de 10µl
Immunohistochemistry - Anti-TOP2A Antibody (B1130) - Antibodies.com
(2)
Voir le roduitTaille d'Essai de 10µg
ELISA - Anti-TOP2A (phospho Ser1106) Antibody (P12-1190) - Antibodies.com
(2)
Voir le roduitTaille d'Essai de 10µg
Immunohistochemistry - Anti-TOP2A (phospho Ser1106) Antibody (A1130) - Antibodies.com
(2)
Voir le roduitTaille d'Essai de 10µg
ELISA - Anti-TOP2A (phospho Thr1343) Antibody (P12-1192) - Antibodies.com
(2)
Voir le roduitTaille d'Essai de 10µg
Western Blot - Anti-TOP2A (phospho Thr1343) Antibody (A8221) - Antibodies.com
(2)
Voir le roduitTaille d'Essai de 10µg
Western Blot - Anti-Topo IIalpha Antibody (R12-2383) - Antibodies.com
Voir le roduitTaille d'Essai de 10µg
Western Blot - Anti-TOP2A Antibody (R12-3642) - Antibodies.com
Voir le roduitTaille d'Essai de 10µg
Western Blot - Anti-TOP2A Antibody (B8221) - Antibodies.com
Voir le roduitTaille d'Essai de 10µg

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