TOP1MT est un gène codé par le symbole TOP1MT. Il est également connu sous le nom de DNA topoisomerase I, mitochondrial. TOP1MT a une masse de 69.87kDa et une longueur d'acide aminé de 601.
Nous proposons 12 des anticorps contre TOP1MT, élevé dans Lapin et Souris, qui sont appropriés pour le WB, IHC, ICC/IF et Cytométrie en Flux avec des échantillons dérivés de Humain et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Releases the supercoiling and torsional tension of DNA introduced during duplication of mitochondrial DNA by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity).
Résumé Entrez
This gene encodes a mitochondrial DNA topoisomerase that plays a role in the modification of DNA topology. The encoded protein is a type IB topoisomerase and catalyzes the transient breaking and rejoining of DNA to relieve tension and DNA supercoiling generated in the mitochondrial genome during replication and transcription. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Spécificité tissulaire
Ubiquitous; highest in skeletal muscle, heart, brain and fetal liver.
Similitudes de séquence
Belongs to the type IB topoisomerase family.
Localisation cellulaire
Mitochondrion.
