TNFSF9 est un gène codé par le symbole TNFSF9. Il est également connu sous le nom de: Tumor necrosis factor ligand superfamily member 9; 4-1BB ligand; 4-1BBL. TNFSF9 a une masse de 26.63kDa et une longueur d'acide aminé de 254.
Nous proposons 13 des anticorps contre TNFSF9, élevé dans Lapin, Souris, Rat et Human, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF, Cytométrie en Flux et IP avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages.
Résumé Entrez
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.
Spécificité tissulaire
Expressed in brain, placenta, lung, skeletal muscle and kidney.
Similitudes de séquence
Belongs to the tumor necrosis factor family.
Localisation cellulaire
Membrane.
