TNFRSF18 est un gène codé par le symbole TNFRSF18. Il est également connu sous le nom de: Tumor necrosis factor receptor superfamily member 18; Activation-inducible TNFR family receptor; Glucocorticoid-induced TNFR-related protein; AITR; GITR. TNFRSF18 a une masse de 26kDa et une longueur d'acide aminé de 241.
Nous proposons 17 des anticorps contre TNFRSF18, élevé dans Lapin, Souris, Rat et Human, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF, Cytométrie en Flux et ChIP avec des échantillons dérivés de Humain et Souris.
Informations sur les Gènes et les Protéines
Résumé UniProt
Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway.
Résumé Entrez
This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Spécificité tissulaire
Expressed in lymph node, peripheral blood leukocytes and weakly in spleen.
Localisation cellulaire
Cell membrane.
