Anticorps TMPRSS3

6 produits

TMPRSS3 est un gène codé par le symbole TMPRSS3. Il est également connu sous le nom de: Transmembrane protease serine 3; Serine protease TADG-12; Tumor-associated differentially-expressed gene 12 protein; ECHOS1; TADG12. TMPRSS3 a une masse de 49.41kDa, une longueur d'acide aminé de 454, et est impliqué dans Deafness, autosomal recessive, 8.

Nous proposons 6 des anticorps contre TMPRSS3, élevé dans Lapin et Chèvre, qui sont appropriés pour le WB, IHC, ELISA et ICC/IF avec des échantillons dérivés de Humain, Souris et Rat.

Informations sur les Gènes et les Protéines

Résumé UniProt
Probable serine protease that plays a role in hearing. Acts as a permissive factor for cochlear hair cell survival and activation at the onset of hearing and is required for saccular hair cell survival (By similarity). Activates ENaC (in vitro).
Résumé Entrez
This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a serine protease domain, a transmembrane domain, an LDL receptor-like domain, and a scavenger receptor cysteine-rich domain. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders. This gene was identified by its association with both congenital and childhood onset autosomal recessive deafness. This gene is expressed in fetal cochlea and many other tissues, and is thought to be involved in the development and maintenance of the inner ear or the contents of the perilymph and endolymph. This gene was also identified as a tumor-associated gene that is overexpressed in ovarian tumors. Alternatively spliced transcript variants have been described.
Spécificité tissulaire
Expressed in many tissues including fetal cochlea. Isoform T is found at increased levels in some carcinomas.
Implication dans la maladie
Deafness, autosomal recessive, 8: A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
Similitudes de séquence
Belongs to the peptidase S1 family.
Modification post-traductionnelle
Undergoes autoproteolytic activation.
Localisation cellulaire
Endoplasmic reticulum membrane.
Liens de base de données
Western Blot - Anti-TMPRSS3 Antibody (C10761) - Antibodies.com
(3)
Voir le roduitTaille d'Essai de 10µg
Western Blot - Anti-TMPRSS3 Antibody (R12-3633) - Antibodies.com
Voir le roduitTaille d'Essai de 10µg
Western Blot - Anti-TMPRSS3 Antibody (A83475) - Antibodies.com
Anti-TMPRSS3 (F440) Antibody from Bioworld Technology (BS2289) - Antibodies.com
(2)
Western blot - TMPRSS3 Antibody from Signalway Antibody (33829) - Antibodies.com
(2)
Immunohistochemistry - TMPRSS3 Antibody from Signalway Antibody (43162) - Antibodies.com

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