TLR8 est un gène codé par le symbole TLR8. Il est également connu sous le nom de Toll-like receptor 8. TLR8 a une masse de 119.83kDa et une longueur d'acide aminé de 1041.
Nous proposons 9 des anticorps contre TLR8, élevé dans Lapin et Souris, qui sont appropriés pour le WB, IHC et ICC/IF avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Endosomal receptor that plays a key role in innate and adaptive immunity (PubMed:25297876). Controls host immune response against pathogens through recognition of RNA degradation products specific to microorganisms that are initially processed by RNASET2 (PubMed:31778653). Upon binding to agonists, undergoes dimerization that brings TIR domains from the two molecules into direct contact, leading to the recruitment of TIR-containing downstream adapter MYD88 through homotypic interaction (PubMed:23520111, PubMed:25599397, PubMed:26929371). In turn, the Myddosome signaling complex is formed involving IRAK4, IRAK1, TRAF6, TRAF3 leading to activation of downstream transcription factors NF-kappa-B and IRF7 to induce proinflammatory cytokines and interferons, respectively (PubMed:16737960, PubMed:17932028, PubMed:29155428).
Résumé Entrez
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X.
Spécificité tissulaire
Expressed in myeloid dendritic cells, monocytes, and monocyte-derived dendritic cells.
Similitudes de séquence
Belongs to the Toll-like receptor family.
Modification post-traductionnelle
Ubiquitinated by RNF216; leading to degradation by the proteasome.
Localisation cellulaire
Endosome membrane.
Endosomal localization confers distinctive proteolytic processing.
