TLE 1 est un gène codé par le symbole TLE1. Il est également connu sous le nom de: Transducin-like enhancer protein 1; E(Sp1) homolog; Enhancer of split groucho-like protein 1; ESG1; TLE1. TLE 1 a une masse de 83.2kDa et une longueur d'acide aminé de 770.
Nous proposons 18 des anticorps contre TLE 1, élevé dans Lapin et Souris, qui sont appropriés pour le WB, IHC, ICC/IF, Cytométrie en Flux et ChIP avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.
Spécificité tissulaire
In all tissues examined, mostly in brain, liver and muscle.
Similitudes de séquence
Belongs to the WD repeat Groucho/TLE family.
Modification post-traductionnelle
Phosphorylated, probably by CDK1. The degree of phosphorylation varies throughout the cell cycle, and is highest at the G2/M transition. Becomes hyperphosphorylated in response to cell differentiation and interaction with HES1 or RUNX1.
Localisation cellulaire
Nucleus.
Nuclear and chromatin-associated, depending on isoforms and phosphorylation status. Hyperphosphorylation decreases the affinity for nuclear components.
