TIMP3 est un gène codé par le symbole TIMP3. Il est également connu sous le nom de: Metalloproteinase inhibitor 3; Protein MIG-5; Tissue inhibitor of metalloproteinases 3; TIMP-3. TIMP3 a une masse de 24.15kDa, une longueur d'acide aminé de 211, et est impliqué dans Sorsby fundus dystrophy.
Nous proposons 11 des anticorps contre TIMP3, élevé dans Lapin, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF et Cytométrie en Flux avec des échantillons dérivés de Humain, Souris, Rat, Bovin, Canin et Cheval.
Informations sur les Gènes et les Protéines
Résumé UniProt
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15.
Résumé Entrez
This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM). Expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in this gene have been associated with the autosomal dominant disorder Sorsby's fundus dystrophy.
Implication dans la maladie
Sorsby fundus dystrophy: Rare autosomal dominant macular disorder with an age of onset in the fourth decade. It is characterized by loss of central vision from subretinal neovascularization and atrophy of the ocular tissues. Generally, macular disciform degeneration develops in the patients eye within 6 months to 6 years.
Similitudes de séquence
Belongs to the protease inhibitor I35 (TIMP) family.
Localisation cellulaire
Secreted > Extracellular space > Extracellular matrix.
