TIM 1 est un gène codé par le symbole HAVCR1. Il est également connu sous le nom de: Hepatitis A virus cellular receptor 1; HAVcr-1; Kidney injury molecule 1; KIM-1; T-cell immunoglobulin and mucin domain-containing protein 1; TIMD-1; T-cell immunoglobulin mucin receptor 1; TIM; T-cell membrane protein 1; HAVCR1; KIM1; TIM1; TIMD1. TIM 1 a une masse de 39.25kDa et une longueur d'acide aminé de 364.
Nous proposons 10 des anticorps contre TIM 1, élevé dans Lapin, Chèvre et Rat, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF et Cytométrie en Flux avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
May play a role in T-helper cell development and the regulation of asthma and allergic diseases. Receptor for TIMD4 (By similarity). May play a role in kidney injury and repair.
Résumé Entrez
The protein encoded by this gene is a membrane receptor for both human hepatitis A virus (HHAV) and TIMD4. The encoded protein may be involved in the moderation of asthma and allergic diseases. The reference genome represents an allele that retains a MTTVP amino acid segment that confers protection against atopy in HHAV seropositive individuals. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 4, 12 and 19.
Spécificité tissulaire
Widely expressed, with highest levels in kidney and testis. Expressed by activated CD4+ T-cells during the development of helper T-cells responses.
Similitudes de séquence
Belongs to the immunoglobulin superfamily. TIM family.
Localisation cellulaire
Membrane.
