Anticorps Thrombomodulin

14 produits

Thrombomodulin est un gène codé par le symbole THBD. Il est également connu sous le nom de: TM; Fetomodulin; THBD; THRM. Thrombomodulin a une masse de 60.33kDa, une longueur d'acide aminé de 575, et est impliqué dans les maladies: Thrombophilia due to thrombomodulin defect; Hemolytic uremic syndrome atypical 6.

Nous proposons 14 des anticorps contre Thrombomodulin, élevé dans Lapin et Souris, qui sont appropriés pour le WB, IHC, ELISA et ICC/IF avec des échantillons dérivés de Humain, Souris et Rat.

Informations sur les Gènes et les Protéines

Résumé UniProt
Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.
Résumé Entrez
The protein encoded by this intronless gene is an endothelial-specific type I membrane receptor that binds thrombin. This binding results in the activation of protein C, which degrades clotting factors Va and VIIIa and reduces the amount of thrombin generated. Mutations in this gene are a cause of thromboembolic disease, also known as inherited thrombophilia.
Spécificité tissulaire
Endothelial cells are unique in synthesizing thrombomodulin.
Implication dans la maladie
Thrombophilia due to thrombomodulin defect: A hemostatic disorder characterized by a tendency to thrombosis.

Hemolytic uremic syndrome atypical 6: An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease.
Modification post-traductionnelle
N-glycosylated.
Localisation cellulaire
Membrane.
Liens de base de données
Western Blot - Anti-Thrombomodulin Antibody (A14527) - Antibodies.com
(6)
Immunohistochemistry - Anti-Thrombomodulin Antibody [THBD/1591] - BSA and Azide free (A253304) - Antibodies.com
(6)
Voir le roduitAnticorps Monospécifique
Immunohistochemistry - Anti-Thrombomodulin Antibody [THBD/1591] (A250124) - Antibodies.com
(6)
Voir le roduitAnticorps Monospécifique
Immunohistochemistry - Anti-Thrombomodulin Antibody [rTHBD/1591] (A250126) - Antibodies.com
(4)
Voir le roduitAnticorps MonospécifiqueAnticorps Recombinant
Immunohistochemistry - Anti-Thrombomodulin Antibody [rTHBD/1591] - BSA and Azide free (A253306) - Antibodies.com
(4)
Voir le roduitAnticorps MonospécifiqueAnticorps Recombinant
Immunohistochemistry - Anti-Thrombomodulin Antibody [THBD/1782] - BSA and Azide free (A253305) - Antibodies.com
(4)
Voir le roduitAnticorps Monospécifique
Immunohistochemistry - Anti-Thrombomodulin Antibody [THBD/1782] (A250125) - Antibodies.com
(4)
Voir le roduitAnticorps Monospécifique
Western Blot - Anti-THBD Antibody (R12-3621) - Antibodies.com
Voir le roduitTaille d'Essai de 10µg
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Voir le roduitTaille d'Essai de 10µg
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Voir le roduitAnticorps Recombinant
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Voir le roduitAnticorps Recombinant
Thrombomodulin (CD141) antibody from Signalway Antibody (22197) - Antibodies.com
(2)
Anti-Thrombomodulin Antibody from Bioworld Technology (BS5650) - Antibodies.com
Western blot - THBD Antibody from Signalway Antibody (35094) - Antibodies.com

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