Anticorps TGF beta

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TGF beta est un gène codé par le symbole TGFB1. Il est également connu sous le nom de: Transforming growth factor beta-1 proprotein; TGFB1; TGFB. TGF beta a une masse de 44.34kDa, une longueur d'acide aminé de 390, et est impliqué dans les maladies: Camurati-Engelmann disease; Inflammatory bowel disease, immunodeficiency, and encephalopathy.

Nous proposons 10 des anticorps contre TGF beta, élevé dans Souris, qui sont appropriés pour le WB, IHC, ELISA et ICC/IF avec des échantillons dérivés de Humain, Souris, Rat, Bovin, Singe, Canin et Hamster.

Informations sur les Gènes et les Protéines

Résumé UniProt
Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively.
Résumé Entrez
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGFB family members. This encoded protein regulates cell proliferation, differentiation and growth, and can modulate expression and activation of other growth factors including interferon gamma and tumor necrosis factor alpha. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease.
Spécificité tissulaire
Highly expressed in bone (PubMed:11746498, PubMed:17827158). Abundantly expressed in articular cartilage and chondrocytes and is increased in osteoarthritis (OA) (PubMed:11746498, PubMed:17827158). Colocalizes with ASPN in chondrocytes within OA lesions of articular cartilage (PubMed:17827158).
Implication dans la maladie
Camurati-Engelmann disease: An autosomal dominant disorder characterized by hyperostosis and sclerosis of the diaphyses of long bones. The disease typically presents in early childhood with pain, muscular weakness and waddling gait, and in some cases other features such as exophthalmos, facial paralysis, hearing difficulties and loss of vision.

Inflammatory bowel disease, immunodeficiency, and encephalopathy: An autosomal recessive disorder characterized by severe infantile inflammatory bowel disease manifesting as bloody diarrhea and failure to thrive, global developmental delay, epilepsy, brain atrophy and encephalopathy. Affected individuals suffer from recurrent infections associated with impaired T-cell response to stimulation and decreased T-cell subsets, including regulatory and helper T cells.
Similitudes de séquence
Belongs to the TGF-beta family.
Modification post-traductionnelle
Transforming growth factor beta-1 proprotein: The precursor proprotein is cleaved in the Golgi apparatus by FURIN to form Transforming growth factor beta-1 (TGF-beta-1) and Latency-associated peptide (LAP) chains, which remain non-covalently linked, rendering TGF-beta-1 inactive.
Localisation cellulaire
Secreted > Extracellular space > Extracellular matrix.
Western Blot - Anti-TGF beta Antibody (MO-C40009A) - Antibodies.com
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SDS-PAGE - Anti-TGF beta Antibody [TGFB/510] - BSA and Azide free (A253299) - Antibodies.com
SDS-PAGE - Anti-TGF beta Antibody [TGFB/510] (A250119) - Antibodies.com
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Western Blot - Anti-TGF beta Antibody (MO-C40009E) - Antibodies.com
Western Blot - Anti-TGF beta Antibody (MO-C40009B) - Antibodies.com
Western Blot - Anti-TGF beta Antibody (MO-C40009F) - Antibodies.com
Western Blot - Anti-TGF beta Antibody (MO-C40009D) - Antibodies.com

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