TCTP est un gène codé par le symbole TPT1. Il est également connu sous le nom de: Translationally-controlled tumor protein; Fortilin; Histamine-releasing factor; HRF; p23; TPT1. TCTP a une masse de 19.6kDa et une longueur d'acide aminé de 172.
Nous proposons 7 des anticorps contre TCTP, élevé dans Lapin, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF et IP avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Involved in calcium binding and microtubule stabilization.
Résumé Entrez
This gene encodes a protein that is a regulator of cellular growth and proliferation. Its mRNA is highly structured and contains an oligopyrimidine tract (5'-TOP) in its 5' untranslated region that functions to repress its translation under quiescent conditions. The encoded protein is involved in a variety of cellular pathways, including apoptosis, protein synthesis and cell division. It binds to and stabilizes microtubules, and removal of this protein through phosphorylation is required for progression through mitotic and meiotic cell divisions. This gene is known to play a role in carcinogenesis, and is upregulated in some cancer cells. Alternative splicing results in multiple transcript variants encoding different isoforms.
Spécificité tissulaire
Found in several healthy and tumoral cells including erythrocytes, hepatocytes, macrophages, platelets, keratinocytes, erythroleukemia cells, gliomas, melanomas, hepatoblastomas, and lymphomas. It cannot be detected in kidney and renal cell carcinoma (RCC). Expressed in placenta and prostate.
Similitudes de séquence
Belongs to the TCTP family.
Localisation cellulaire
Cytoplasm.
