TCP1 epsilon est un gène codé par le symbole CCT5. Il est également connu sous le nom de: T-complex protein 1 subunit epsilon; TCP-1-epsilon; CCT-epsilon; CCT5; CCTE; KIAA0098. TCP1 epsilon a une masse de 59.67kDa, une longueur d'acide aminé de 541, et est impliqué dans Neuropathy, hereditary sensory, with spastic paraplegia, autosomal recessive.
Nous proposons 7 des anticorps contre TCP1 epsilon, élevé dans Lapin, qui sont appropriés pour le WB, IHC, ELISA et ICC/IF avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). The TRiC complex plays a role in the folding of actin and tubulin (Probable).
Résumé Entrez
The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Mutations in this gene cause hereditary sensory and autonomic neuropathy with spastic paraplegia (HSNSP). Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 5 and 13.
Implication dans la maladie
Neuropathy, hereditary sensory, with spastic paraplegia, autosomal recessive: A disease characterized by spastic paraplegia and progressive distal sensory neuropathy leading to mutilating ulcerations of the upper and lower limbs.
Similitudes de séquence
Belongs to the TCP-1 chaperonin family.
Localisation cellulaire
Cytoplasm. Cytoplasm > Cytoskeleton > Microtubule organizing center > Centrosome.
