Synaptotagmin 1 est un gène codé par le symbole SYT1. Il est également connu sous le nom de: Synaptotagmin-1; Synaptotagmin I; SytI; p65; SYT1; SVP65; SYT. Synaptotagmin 1 a une masse de 47.57kDa, une longueur d'acide aminé de 422, et est impliqué dans Baker-Gordon syndrome.
Nous proposons 9 des anticorps contre Synaptotagmin 1, élevé dans Lapin et Chèvre, qui sont appropriés pour le WB, IHC, ELISA et ICC/IF avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Calcium sensor that participates in triggering neurotransmitter release at the synapse (By similarity). May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse (By similarity). It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. Plays a role in dendrite formation by melanocytes (PubMed:23999003).
Résumé Entrez
The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin-1 participates in triggering neurotransmitter release at the synapse (Fernandez-Chacon et al., 2001
Spécificité tissulaire
Expressed in melanocytes (PubMed:23999003).
Implication dans la maladie
Baker-Gordon syndrome: An autosomal dominant neurodevelopmental disorder characterized by infantile hypotonia, congenital ophthalmic abnormalities, involuntary and hyperkinetic movements, stereotypic behavior, poor or absent speech, EEG abnormalities, and global developmental delay varying in severity from moderate to profound. Behavioral characteristics include sleep disturbance and episodic agitation.
Similitudes de séquence
Belongs to the synaptotagmin family.
Modification post-traductionnelle
Glycosylated.
Localisation cellulaire
Cytoplasmic vesicle > Secretory vesicle membrane. Cytoplasmic vesicle > Secretory vesicle > Synaptic vesicle membrane. Cytoplasmic vesicle > Secretory vesicle > Chromaffin granule membrane. Cytoplasm.
