STK39 est un gène codé par le symbole STK39. Il est également connu sous le nom de: STE20/SPS1-related proline-alanine-rich protein kinase; Ste-20-related kinase; DCHT; Serine/threonine-protein kinase 39; SPAK. STK39 a une masse de 59.47kDa et une longueur d'acide aminé de 545.
Nous proposons 16 des anticorps contre STK39, élevé dans Lapin, qui sont appropriés pour le WB, IHC et ELISA avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
May act as a mediator of stress-activated signals. Mediates the inhibition of SLC4A4, SLC26A6 as well as CFTR activities by the WNK scaffolds, probably through phosphorylation. Phosphorylates RELT.
Résumé Entrez
This gene encodes a serine/threonine kinase that is thought to function in the cellular stress response pathway. The kinase is activated in response to hypotonic stress, leading to phosphorylation of several cation-chloride-coupled cotransporters. The catalytically active kinase specifically activates the p38 MAP kinase pathway, and its interaction with p38 decreases upon cellular stress, suggesting that this kinase may serve as an intermediate in the response to cellular stress.
Spécificité tissulaire
Predominantly expressed in brain and pancreas followed by heart, lung, kidney, skeletal muscle, liver, placenta and testis.
Similitudes de séquence
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
Modification post-traductionnelle
Phosphorylated at Ser-309 by PRKCQ (PubMed:14988727). Autophosphorylation at Thr-231 positively regulates its activity (By similarity).
Localisation cellulaire
Cytoplasm. Nucleus.
Nucleus when caspase-cleaved.
