STAT4 est un gène codé par le symbole STAT4. Il est également connu sous le nom de Signal transducer and activator of transcription 4. STAT4 a une masse de 85.94kDa, une longueur d'acide aminé de 748, et est impliqué dans les maladies: Systemic lupus erythematosus 11; Rheumatoid arthritis.
Nous proposons 13 des anticorps contre STAT4, élevé dans Lapin, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF et IP avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Carries out a dual function: signal transduction and activation of transcription. Involved in IL12 signaling.
Résumé Entrez
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein.
Implication dans la maladie
Systemic lupus erythematosus 11: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.
Rheumatoid arthritis: An inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures.
Similitudes de séquence
Belongs to the transcription factor STAT family.
Modification post-traductionnelle
Tyrosine phosphorylated. Serine phosphorylation is also required for maximal transcriptional activity (By similarity).
Localisation cellulaire
Cytoplasm. Nucleus.
Translocated into the nucleus in response to phosphorylation.
