STAM2 est un gène codé par le symbole STAM2. Il est également connu sous le nom de: Signal transducing adapter molecule 2; STAM-2; Hrs-binding protein; HBP. STAM2 a une masse de 58.16kDa et une longueur d'acide aminé de 525.
Nous proposons 7 des anticorps contre STAM2, élevé dans Lapin et Chèvre, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF et Cytométrie en Flux avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity).
Résumé Entrez
The protein encoded by this gene is closely related to STAM, an adaptor protein involved in the downstream signaling of cytokine receptors, both of which contain a SH3 domain and the immunoreceptor tyrosine-based activation motif (ITAM). Similar to STAM, this protein acts downstream of JAK kinases, and is phosphorylated in response to cytokine stimulation. This protein and STAM thus are thought to exhibit compensatory effects on the signaling pathway downstream of JAK kinases upon cytokine stimulation.
Spécificité tissulaire
Ubiquitously expressed.
Similitudes de séquence
Belongs to the STAM family.
Modification post-traductionnelle
Phosphorylated in response to IL-2, GM-CSF, EGF and PDGF.
Localisation cellulaire
Cytoplasm. Early endosome membrane.
