spindlin 1 est un gène codé par le symbole SPIN1. Il est également connu sous le nom de: Spindlin-1; Ovarian cancer-related protein; Spindlin1; SPIN1; OCR; SPIN. spindlin 1 a une masse de 29.6kDa et une longueur d'acide aminé de 262.
Nous proposons 7 des anticorps contre spindlin 1, élevé dans Lapin, qui sont appropriés pour le WB, IHC, ELISA et ICC/IF avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at 'Lys-4' and asymmetrically dimethylated at 'Arg-8' (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway downstream of PRMT2. In case of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway (PubMed:24589551). Overexpression induces metaphase arrest and chromosomal instability. Localizes to active rDNA loci and promotes the expression of rRNA genes (PubMed:21960006). May play a role in cell-cycle regulation during the transition from gamete to embryo. Involved in oocyte meiotic resumption, a process that takes place before ovulation to resume meiosis of oocytes blocked in prophase I: may act by regulating maternal transcripts to control meiotic resumption.
Spécificité tissulaire
Highly expressed in ovarian cancer tissues.
Similitudes de séquence
Belongs to the SPIN/STSY family.
Modification post-traductionnelle
Phosphorylated during oocyte meiotic maturation.
Localisation cellulaire
Nucleus. Nucleus > Nucleolus.
