SPARC est un gène codé par le symbole SPARC. Il est également connu sous le nom de: Basement-membrane protein 40; BM-40; Osteonectin; ON; Secreted protein acidic and rich in cysteine. SPARC a une masse de 34.63kDa, une longueur d'acide aminé de 303, et est impliqué dans Osteogenesis imperfecta 17.
Nous proposons 29 des anticorps contre SPARC, élevé dans Lapin et Souris, qui sont appropriés pour le WB, IHC, ELISA et ICC/IF avec des échantillons dérivés de Humain, Souris, Rat, Bovin, Porcin et Lapin.
Informations sur les Gènes et les Protéines
Résumé UniProt
Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.
Résumé Entrez
This gene encodes a cysteine-rich acidic matrix-associated protein. The encoded protein is required for the collagen in bone to become calcified but is also involved in extracellular matrix synthesis and promotion of changes to cell shape. The gene product has been associated with tumor suppression but has also been correlated with metastasis based on changes to cell shape which can promote tumor cell invasion. Three transcript variants encoding different isoforms have been found for this gene.
Implication dans la maladie
Osteogenesis imperfecta 17: An autosomal recessive form of osteogenesis imperfecta, a connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma. Disease severity ranges from very mild forms without fractures to intrauterine fractures and perinatal lethality. Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis imperfecta, hearing loss, and blue sclerae.
Similitudes de séquence
Belongs to the SPARC family.
Localisation cellulaire
Secreted > Extracellular space > Extracellular matrix > Basement membrane.
In or around the basement membrane.
