SnoN est un gène codé par le symbole SKIL. Il est également connu sous le nom de: Ski-like protein; Ski-related oncogene; Ski-related protein; SKIL; SNO. SnoN a une masse de 76.98kDa et une longueur d'acide aminé de 684.
Nous proposons 6 des anticorps contre SnoN, élevé dans Lapin, qui sont appropriés pour le WB, IHC et ELISA avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
May have regulatory role in cell division or differentiation in response to extracellular signals.
Résumé Entrez
The protein encoded by this gene is a component of the SMAD pathway, which regulates cell growth and differentiation through transforming growth factor-beta (TGFB). In the absence of ligand, the encoded protein binds to the promoter region of TGFB-responsive genes and recruits a nuclear repressor complex. TGFB signaling causes SMAD3 to enter the nucleus and degrade this protein, allowing these genes to be activated. Four transcript variants encoding three different isoforms have been found for this gene.
Spécificité tissulaire
Isoform SNON and isoform SNOA are widely expressed. Highest expression is found in skeletal muscle, followed by placenta and lung. Lowest expression in heart, brain and pancreas. Isoform SNOI expression is restricted to skeletal muscle.
Similitudes de séquence
Belongs to the SKI family.
Modification post-traductionnelle
Ubiquitinated by RNF111 and RNF165, promoting proteasomal degradation, leading to enhance the BMP-Smad signaling.
