SNAP23 est un gène codé par le symbole SNAP23. Il est également connu sous le nom de: Synaptosomal-associated protein 23; SNAP-23; Vesicle-membrane fusion protein SNAP-23. SNAP23 a une masse de 23.35kDa et une longueur d'acide aminé de 211.
Nous proposons 6 des anticorps contre SNAP23, élevé dans Lapin et Chèvre, qui sont appropriés pour le WB, IHC et ELISA avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion.
Résumé Entrez
Specificity of vesicular transport is regulated, in part, by the interaction of a vesicle-associated membrane protein termed synaptobrevin/VAMP with a target compartment membrane protein termed syntaxin. These proteins, together with SNAP25 (synaptosome-associated protein of 25 kDa), form a complex which serves as a binding site for the general membrane fusion machinery. Synaptobrevin/VAMP and syntaxin are believed to be involved in vesicular transport in most, if not all cells, while SNAP25 is present almost exclusively in the brain, suggesting that a ubiquitously expressed homolog of SNAP25 exists to facilitate transport vesicle/target membrane fusion in other tissues. The protein encoded by this gene is structurally and functionally similar to SNAP25 and binds tightly to multiple syntaxins and synaptobrevins/VAMPs. It is an essential component of the high affinity receptor for the general membrane fusion machinery and is an important regulator of transport vesicle docking and fusion. Two alternative transcript variants encoding different protein isoforms have been described for this gene.
Spécificité tissulaire
Ubiquitous. Highest levels where found in placenta.
Similitudes de séquence
Belongs to the SNAP-25 family.
Localisation cellulaire
Cell membrane. Cell membrane. Cell junction > Synapse > Synaptosome.
Mainly localized to the plasma membrane.
