Smoothened est un gène codé par le symbole SMO. Il est également connu sous le nom de: Smoothened homolog; SMO; Protein Gx; SMOH. Smoothened a une masse de 86.4kDa, une longueur d'acide aminé de 787, et est impliqué dans Curry-Jones syndrome.
Nous proposons 6 des anticorps contre Smoothened, élevé dans Lapin, qui sont appropriés pour le WB, ELISA et Dot avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7, GLI2 and GLI3 in the cilia (PubMed:19592253). Interacts with DLG5 at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity).
Résumé Entrez
The protein encoded by this gene is a G protein-coupled receptor that interacts with the patched protein, a receptor for hedgehog proteins. The encoded protein tranduces signals to other proteins after activation by a hedgehog protein/patched protein complex.
Implication dans la maladie
Curry-Jones syndrome: A multisystem disorder characterized by patchy skin lesions, polysyndactyly, diverse cerebral malformations, unicoronal craniosynostosis, iris colobomas, microphthalmia, and intestinal malrotation with myofibromas or hamartomas.
Similitudes de séquence
Belongs to the G-protein coupled receptor Fz/Smo family.
Localisation cellulaire
Membrane. Cell projection > Cilium.
