Siglec 7 est un gène codé par le symbole SIGLEC7. Il est également connu sous le nom de: Sialic acid-binding Ig-like lectin 7; Siglec-7; Adhesion inhibitory receptor molecule 1; AIRM-1; CDw328; D-siglec; QA79 membrane protein; p75; SIGLEC7; AIRM1. Siglec 7 a une masse de 51.14kDa et une longueur d'acide aminé de 467.
Nous proposons 14 des anticorps contre Siglec 7, élevé dans Lapin et Souris, qui sont appropriés pour le WB, IHC, ELISA, Cytométrie en Flux et IP avec des échantillons dérivés de Humain.
Informations sur les Gènes et les Protéines
Résumé UniProt
Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro).
Spécificité tissulaire
Predominantly expressed by resting and activated natural killer cells and at lower levels by granulocytes and monocytes. High expression found in placenta, liver, lung, spleen, and peripheral blood leukocytes.
Similitudes de séquence
Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
Modification post-traductionnelle
Tyrosine phosphorylated.
Localisation cellulaire
Membrane.
