SH2D1B est un gène codé par le symbole SH2D1B. Il est également connu sous le nom de: SH2 domain-containing protein 1B; EWS/FLI1-activated transcript 2; EAT-2; EAT2. SH2D1B a une masse de 15.3kDa et une longueur d'acide aminé de 132.
Nous proposons 2 des anticorps contre SH2D1B, élevé dans Lapin, qui sont appropriés pour le IHC et ELISA avec des échantillons dérivés de Humain.
Informations sur les Gènes et les Protéines
Résumé UniProt
Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as CD84, SLAMF1, LY9 and CD244 (PubMed:11689425). In SLAM signaling seems to cooperate with SH2D1A/SAP. Plays a role in regulation of effector functions of natural killer (NK) cells by controlling signal transduction through CD244/2B4 without effecting its tyrosine phosphorylation; downstream signaling involves PLCG1 and ERK activation (PubMed:24687958). Activation of SLAMF7-mediated NK cell function does not effect receptor tyrosine phosphorylation but distal signaling (By similarity). In the context of NK cell-mediated cytotoxicity does not enhance conjugate formation with target cells but stimulates polarization of the microtubule-organizing center and cytotoxic granules toward the NK cell synapse (PubMed:24687958). Negatively regulates CD40-induced cytokine production in dendritic cells downstream of SLAM family receptors probably by inducing activation of the PI3K pathway to inhibit p38 MAPK and JNK activation (By similarity).
Résumé Entrez
By binding phosphotyrosines through its free SRC (MIM 190090) homology-2 (SH2) domain, EAT2 regulates signal transduction through receptors expressed on the surface of antigen-presenting cells (Morra et al., 2001
