SGLT1 est un gène codé par le symbole SLC5A1. Il est également connu sous le nom de: Sodium/glucose cotransporter 1; Na(+)/glucose cotransporter 1; High affinity sodium-glucose cotransporter; Solute carrier family 5 member 1; SLC5A1; NAGT. SGLT1 a une masse de 73.5kDa, une longueur d'acide aminé de 664, et est impliqué dans Congenital glucose/galactose malabsorption.
Nous proposons 13 des anticorps contre SGLT1, élevé dans Lapin et Chèvre, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF et IP avec des échantillons dérivés de Humain, Souris, Rat, Singe et Mouton.
Informations sur les Gènes et les Protéines
Résumé UniProt
Actively transports glucose into cells by Na(+) cotransport with a Na(+) to glucose coupling ratio of 2:1. Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules.
Résumé Entrez
This gene encodes a member of the sodium-dependent glucose transporter (SGLT) family. The encoded integral membrane protein is the primary mediator of dietary glucose and galactose uptake from the intestinal lumen. Mutations in this gene have been associated with glucose-galactose malabsorption. Multiple transcript variants encoding different isoforms have been found for this gene.
Spécificité tissulaire
Expressed mainly in intestine and kidney.
Implication dans la maladie
Congenital glucose/galactose malabsorption: Intestinal monosaccharide transporter deficiency. It is an autosomal recessive disorder manifesting itself within the first weeks of life. It is characterized by severe diarrhea and dehydration which are usually fatal unless glucose and galactose are eliminated from the diet.
Similitudes de séquence
Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
Modification post-traductionnelle
N-glycosylation is not necessary for the cotransporter function.
Localisation cellulaire
Membrane.
