SFRP4 est un gène codé par le symbole SFRP4. Il est également connu sous le nom de: Secreted frizzled-related protein 4; sFRP-4; Frizzled protein, human endometrium; FrpHE; FRPHE. SFRP4 a une masse de 39.83kDa, une longueur d'acide aminé de 346, et est impliqué dans Pyle disease.
Nous proposons 6 des anticorps contre SFRP4, élevé dans Lapin et Chèvre, qui sont appropriés pour le WB, IHC, ELISA et ICC/IF avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types (By similarity). SFRP4 plays a role in bone morphogenesis. May also act as a regulator of adult uterine morphology and function. May also increase apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling (By similarity). Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake (PubMed:12952927).
Résumé Entrez
Secreted frizzled-related protein 4 (SFRP4) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. The expression of SFRP4 in ventricular myocardium correlates with apoptosis related gene expression.
Spécificité tissulaire
Expressed in mesenchymal cells. Highly expressed in the stroma of proliferative endometrium. Expressed in cardiomyocytes. Shows moderate to strong expression in ovarian tumors with expression increasing as the tumor stage increases. In ovarian tumors, expression levels are inversely correlated with expression of CTNNB1 (at protein level).
Implication dans la maladie
Pyle disease: A disorder characterized by cortical-bone thinning, limb deformity, bone fragility and fractures.
Similitudes de séquence
Belongs to the secreted frizzled-related protein (sFRP) family.
Localisation cellulaire
Secreted.
Cytoplasmic in ovarian tumor cells.
