Separase est un gène codé par le symbole ESPL1. Il est également connu sous le nom de: Separin; Caspase-like protein ESPL1; Extra spindle poles-like 1 protein; ESPL1; ESP1; KIAA0165. Separase a une masse de 233.18kDa et une longueur d'acide aminé de 2120.
Nous proposons 8 des anticorps contre Separase, élevé dans Lapin, qui sont appropriés pour le WB, IHC, ELISA et ICC/IF avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms.
Résumé Entrez
Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 300826) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21; MIM 606462) by ESPL1, or separase, which initiates the final separation of sister chromatids (Sun et al., 2009
Modification post-traductionnelle
Autocleaves. This function, which is not essential for its protease activity, is unknown.
Localisation cellulaire
Cytoplasm. Nucleus.
