SENP2 est un gène codé par le symbole SENP2. Il est également connu sous le nom de: Sentrin-specific protease 2; Axam2; SMT3-specific isopeptidase 2; Smt3ip2; Sentrin/SUMO-specific protease KIAA1331. SENP2 a une masse de 67.86kDa et une longueur d'acide aminé de 589.
Nous proposons 7 des anticorps contre SENP2, élevé dans Lapin et Souris, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF et Cytométrie en Flux avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Protease that catalyzes two essential functions in the SUMO pathway. The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins. The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway. Deconjugates SUMO2 from MTA1. Plays a dynamic role in adipogenesis by desumoylating and promoting the stabilization of CEBPB (PubMed:20194620).
Résumé Entrez
SUMO1 (UBL1; MIM 601912) is a small ubiquitin-like protein that can be covalently conjugated to other proteins. SENP2 is one of a group of enzymes that process newly synthesized SUMO1 into the conjugatable form and catalyze the deconjugation of SUMO1-containing species.
Similitudes de séquence
Belongs to the peptidase C48 family.
Modification post-traductionnelle
Polyubiquitinated; which leads to proteasomal degradation.
Localisation cellulaire
Nucleus > Nuclear pore complex. Nucleus membrane. Cytoplasm.
Shuttles between cytoplasm and nucleus.
