Scavenging Receptor SR-BI est un gène codé par le symbole SCARB1. Il est également connu sous le nom de: Scavenger receptor class B member 1; SRB1; CD36 and LIMPII analogous 1; CLA-1; CD36 antigen-like 1; Collagen type I receptor, thrombospondin receptor-like 1; SR-BI; SCARB1; CD36L1; CLA1. Scavenging Receptor SR-BI a une masse de 60.88kDa et une longueur d'acide aminé de 552.
Nous proposons 8 des anticorps contre Scavenging Receptor SR-BI, élevé dans Lapin et Chèvre, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF et Cytométrie en Flux avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells (PubMed:12016218, PubMed:12519372, PubMed:21226579). Receptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux (PubMed:26965621). Also facilitates the flux of free and esterified cholesterol between the cell surface and apoB-containing lipoproteins and modified lipoproteins, although less efficiently than HDL. May be involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity (PubMed:12016218).
Résumé Entrez
The protein encoded by this gene is a plasma membrane receptor for high density lipoprotein cholesterol (HDL). The encoded protein mediates cholesterol transfer to and from HDL. In addition, this protein is a receptor for hepatitis C virus glycoprotein E2. Two transcript variants encoding different isoforms have been found for this gene.
Spécificité tissulaire
Widely expressed.
Similitudes de séquence
Belongs to the CD36 family.
Modification post-traductionnelle
N-glycosylated.
Localisation cellulaire
Cell membrane. Membrane > Caveola.
Predominantly localized to cholesterol and sphingomyelin-enriched domains within the plasma membrane, called caveolae.
