S100 calcium binding protein A14 est un gène codé par le symbole S100A14. Il est également connu sous le nom de: Protein S100-A14; S100 calcium-binding protein A14; S114; S100A14; S100A15. S100 calcium binding protein A14 a une masse de 11.66kDa et une longueur d'acide aminé de 104.
Nous proposons 10 des anticorps contre S100 calcium binding protein A14, élevé dans Lapin et Souris, qui sont appropriés pour le WB, IHC, ELISA et ICC/IF avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Modulates P53/TP53 protein levels, and thereby plays a role in the regulation of cell survival and apoptosis. Depending on the context, it can promote cell proliferation or apoptosis. Plays a role in the regulation of cell migration by modulating the levels of MMP2, a matrix protease that is under transcriptional control of P53/TP53. Does not bind calcium.
Résumé Entrez
This gene encodes a member of the S100 protein family which contains an EF-hand motif and binds calcium. The gene is located in a cluster of S100 genes on chromosome 1. Levels of the encoded protein have been found to be lower in cancerous tissue and associated with metastasis suggesting a tumor suppressor function (PMID: 19956863, 19351828).
Spécificité tissulaire
Expressed at highest levels in colon and at moderate levels in thymus, kidney, liver, small intestine, and lung. Low expression in heart and no expression is seen in brain, skeletal muscle, spleen, placenta and peripheral blood leukocytes.
Similitudes de séquence
Belongs to the S-100 family.
Localisation cellulaire
Cytoplasm.
