RRAGA est un gène codé par le symbole RRAGA. Il est également connu sous le nom de: Ras-related GTP-binding protein A; Rag A; Adenovirus E3 14.7 kDa-interacting protein 1; FIP-1. RRAGA a une masse de 36.57kDa et une longueur d'acide aminé de 313.
Nous proposons 7 des anticorps contre RRAGA, élevé dans Lapin, qui sont appropriés pour le WB, IHC, ELISA et ICC/IF avec des échantillons dérivés de Humain, Souris, Rat, Hamster et Xenopus.
Informations sur les Gènes et les Protéines
Résumé UniProt
Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade (PubMed:20381137, PubMed:24095279, PubMed:25936802). Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form (PubMed:20381137, PubMed:24095279, PubMed:25936802). In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB (PubMed:20381137, PubMed:25936802). Involved in the RCC1/Ran-GTPase pathway (PubMed:9394008). May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death (PubMed:8995684).
Spécificité tissulaire
Ubiquitously expressed with highest levels of expression in skeletal muscle, heart, and brain.
Similitudes de séquence
Belongs to the GTR/RAG GTP-binding protein family.
Modification post-traductionnelle
Ubiquitinated. 'Lys-68'-linked polyubiquitination of the GDP-bound inactive form of RRAGA by RNF152 is increased in response to amino acid starvation. Polyubiquitination promotes interaction with the GATOR1 complex. This does not affect RRAGA degradation.
Localisation cellulaire
Cytoplasm. Nucleus. Lysosome.
Predominantly cytoplasmic. May shuttle between the cytoplasm and nucleus, depending on the bound nucleotide state (PubMed:8995684, PubMed:9394008). Colocalizes in vivo with adenovirus E3-14.7K mainly to the cytoplasm especially near the nuclear membrane and in discrete foci on or near the plasma membrane (PubMed:8995684).
