Rhodopsin est un gène codé par le symbole RHO. Il est également connu sous le nom de: Opsin-2; RHO; OPN2. Rhodopsin a une masse de 38.89kDa, une longueur d'acide aminé de 348, et est impliqué dans les maladies: Retinitis pigmentosa 4; Night blindness, congenital stationary, autosomal dominant 1.
Nous proposons 10 des anticorps contre Rhodopsin, élevé dans Lapin et Souris, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF et IP avec des échantillons dérivés de Humain, Souris, Rat, Bovin, Porcin, Cheval et Mammifère.
Informations sur les Gènes et les Protéines
Résumé UniProt
Photoreceptor required for image-forming vision at low light intensity (PubMed:8107847, PubMed:7846071). Required for photoreceptor cell viability after birth (PubMed:2215617, PubMed:12566452). Light-induced isomerization of the chromophore 11-cis-retinal to all-trans-retinal triggers a conformational change that activates signaling via G-proteins (PubMed:8107847, PubMed:28524165, PubMed:26200343, PubMed:28753425). Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling (PubMed:28524165, PubMed:26200343).
Résumé Entrez
The protein encoded by this gene is found in rod cells in the back of the eye and is essential for vision in low-light conditions. The encoded protein binds to 11-cis retinal and is activated when light hits the retinal molecule. Defects in this gene are a cause of congenital stationary night blindness.
Spécificité tissulaire
Rod shaped photoreceptor cells which mediate vision in dim light.
Implication dans la maladie
Retinitis pigmentosa 4: A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
Night blindness, congenital stationary, autosomal dominant 1: A non-progressive retinal disorder characterized by impaired night vision, often associated with nystagmus and myopia.
Similitudes de séquence
Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
Modification post-traductionnelle
Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region (By similarity). After activation by light, phosphorylated by GRK1 (in vitro) (PubMed:28524165).
Localisation cellulaire
Membrane. Cell projection > Cilium > Photoreceptor outer segment.
Synthesized in the inner segment (IS) of rod photoreceptor cells before vectorial transport to disk membranes in the rod outer segment (OS) photosensory cilia.
