RHOD est un gène codé par le symbole RHOD. Il est également connu sous le nom de: Rho-related GTP-binding protein Rho-related protein HP1; RhoHP1; ARHD. RHOD a une masse de 23.41kDa et une longueur d'acide aminé de 210.
Nous proposons 7 des anticorps contre RHOD, élevé dans Lapin, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF et IP avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Involved in endosome dynamics. May coordinate membrane transport with the function of the cytoskeleton. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Participates in the reorganization of actin cytoskeleton; the function seems to involve WHAMM and includes regulation of filopodia formation and actin filament bundling. Can modulate the effect of DAPK3 in reorganization of actin cytoskeleton and focal adhesion dissolution.
Résumé Entrez
Ras homolog, or Rho, proteins interact with protein kinases and may serve as targets for activated GTPase. They play a critical role in muscle differentiation. The protein encoded by this gene binds GTP and is a member of the small GTPase superfamily. It is involved in endosome dynamics and reorganization of the actin cytoskeleton, and it may coordinate membrane transport with the function of the cytoskeleton. Two transcript variants encoding different isoforms have been found for this gene.
Spécificité tissulaire
Heart, placenta, liver, skeletal muscle, and pancreas and, with weaker intensity, in several other tissues.
Similitudes de séquence
Belongs to the small GTPase superfamily. Rho family.
Localisation cellulaire
Cell membrane. Early endosome.
Colocalizes with RAB5 to early endosomes (By similarity).
