Retinoic Acid Receptor gamma est un gène codé par le symbole RARG. Il est également connu sous le nom de: RAR-gamma; Nuclear receptor subfamily 1 group B member 3; RARG; NR1B3. Retinoic Acid Receptor gamma a une masse de 50.34kDa et une longueur d'acide aminé de 454.
Nous proposons 6 des anticorps contre Retinoic Acid Receptor gamma, élevé dans Lapin, qui sont appropriés pour le WB, IHC et ICC/IF avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. Required for limb bud development. In concert with RARA or RARB, required for skeletal growth, matrix homeostasis and growth plate function (By similarity).
Résumé Entrez
This gene encodes a retinoic acid receptor that belongs to the nuclear hormone receptor family. Retinoic acid receptors (RARs) act as ligand-dependent transcriptional regulators. When bound to ligands, RARs activate transcription by binding as heterodimers to the retinoic acid response elements (RARE) found in the promoter regions of the target genes. In their unbound form, RARs repress transcription of their target genes. RARs are involved in various biological processes, including limb bud development, skeletal growth, and matrix homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Spécificité tissulaire
Expressed in aortic endothelial cells (at protein level).
Similitudes de séquence
Belongs to the nuclear hormone receptor family. NR1 subfamily.
Localisation cellulaire
Nucleus. Cytoplasm.
