Anticorps Rel B

8 produits

Rel B est un gène codé par le symbole RELB. Il est également connu sous le nom de: Transcription factor RelB; I-Rel; RELB. Rel B a une masse de 62.13kDa, une longueur d'acide aminé de 579, et est impliqué dans Immunodeficiency 53.

Nous proposons 8 des anticorps contre Rel B, élevé dans Lapin et Souris, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF et IP avec des échantillons dérivés de Humain, Souris et Rat.

Informations sur les Gènes et les Protéines

Résumé UniProt
NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional activators. RELB neither associates with DNA nor with RELA/p65 or REL. Stimulates promoter activity in the presence of NFKB2/p49. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer in a CRY1/CRY2 independent manner. Increased repression of the heterodimer is seen in the presence of NFKB2/p52. Is required for both T and B lymphocyte maturation and function (PubMed:26385063).
Implication dans la maladie
Immunodeficiency 53: An autosomal recessive primary immunodeficiency apparent from early infancy and resulting in recurrent infections, severe autoimmune skin disease rheumatoid arthritis, and failure to thrive. Immunologic workup shows increased CD4+/CD8+ ratio, impaired T-cell proliferative response to multiple antigen, T-cell developmental and functional defects, and impaired ability to produce specific immunoglobulins.
Modification post-traductionnelle
Phosphorylation at 'Thr-103' and 'Ser-573' is followed by proteasomal degradation.
Localisation cellulaire
Nucleus. Cytoplasm > Cytoskeleton > Microtubule organizing center > Centrosome.

Colocalizes with NEK6 in the centrosome.
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Immunohistochemistry - Anti-RelB (phospho Ser552) Antibody (A7212) - Antibodies.com
(2)
Voir le roduitTaille d'Essai de 10µg
Western Blot - Anti-Rel B Antibody (A11158) - Antibodies.com
(4)
Western Blot - Anti-RelB Antibody (B7212) - Antibodies.com
Voir le roduitTaille d'Essai de 10µg
Western blot - RelB (Phospho-Ser573) Antibody from Signalway Antibody (11255) - Antibodies.com
(2)
Western blot - RelB (Ab-573) Antibody from Signalway Antibody (21247) - Antibodies.com
RELB Antibody from Signalway Antibody (37866) - Antibodies.com
Anti-Rel B (S552) Antibody from Bioworld Technology (BS70007) - Antibodies.com

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