Radixin est un gène codé par le symbole RDX. Il est également connu sous le nom de RDX. Radixin a une masse de 68.56kDa, une longueur d'acide aminé de 583, et est impliqué dans Deafness, autosomal recessive, 24.
Nous proposons 6 des anticorps contre Radixin, élevé dans Lapin et Chèvre, qui sont appropriés pour le WB, IHC, ELISA et ICC/IF avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane.
Résumé Entrez
Radixin is a cytoskeletal protein that may be important in linking actin to the plasma membrane. It is highly similar in sequence to both ezrin and moesin. The radixin gene has been localized by fluorescence in situ hybridization to 11q23. A truncated version representing a pseudogene (RDXP2) was assigned to Xp21.3. Another pseudogene that seemed to lack introns (RDXP1) was mapped to 11p by Southern and PCR analyses. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Implication dans la maladie
Deafness, autosomal recessive, 24: A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
Modification post-traductionnelle
Phosphorylated by tyrosine-protein kinases. Phosphorylation by ROCK2 suppresses the head-to-tail association of the N-terminal and C-terminal halves resulting in an opened conformation which is capable of actin and membrane-binding (By similarity).
Localisation cellulaire
Cell membrane. Cytoplasm > Cytoskeleton. Cleavage furrow. Cell projection > Microvillus.
Highly concentrated in the undercoat of the cell-to-cell adherens junction and the cleavage furrow in the interphase and mitotic phase, respectively.
